Influenza a antibodies in cervine animals
Identifieur interne : 002849 ( Main/Exploration ); précédent : 002848; suivant : 002850Influenza a antibodies in cervine animals
Auteurs : W. Ehrengut ; D. E. Sarateanu ; G. Rutter [Allemagne]Source :
- Infection [ 0300-8126 ] ; 1980-03-01.
English descriptors
- Teeft :
- Animal influenza, Animal origin, Avian, Avian influenza viruses, Cervine, Cervine animals, Cervine sera, Experimental immunology, Genetic interaction, Hemagglutinin subunits, Hong kong influenza, Human sera, Human strains, Influenza, Influenza antibodies, Influenza virus, Influenza viruses, Pandemic, Pandemic influenza, Virology, Virus, Vivo production, Wide variety, Wild birds.
Abstract
Summary: In the haemagglutination inhibition (HI) test, 20 cervine sera, most of which came from Northern Germany, were treated with receptor destroying enzyme (RDE) and 11 sera were found to contain antibodies against the H1N1 (A/USSR 90/77) and H3N2 (A/Victoria 13/75, A/Texas 1/77) influenza viruses. Only two sera contained antibodies against H3N2 viruses, and seven sera were negative. Evidence of the specificity of influenza antibodies was provided by the following findings: 1) the IgG serum extracts showed the same inhibitory activity of haemagglutinin as the RDE treated sera; 2) addition of protein A led to an increase in the HI titers; 3) in the haemolysis in gel test, some of the HI positive sera formed haemolysis rings of the same diameter as hyperimmune antiinfluenza A (H1N1) serum; and 4) the cervine sera reacted positively in the neuraminidase inhibition (NI) test. It is remarkable that influenza H1N1 antibodies were found in the serum of one cervine before this virus strain appeared in humans.
Zusammenfassung: Von 20 Sera der Spezies Cervus, meist aus Norddeutschland stammend, die mit „receptor destroying enzyme“ (RDE) behandelt worden waren, enthielten elf hämagglutinationshemmende Antikörper gegen H1N1 (A/USSR 90/77)- und H3N2 (A/Victoria 13/75, A/Texas 1/77)-Influenza-Viren. Nur zwei Sera besaßen Antikörper gegen H3N2-Viren, und sieben Sera waren sero-negativ. Die Spezifität der Antikörper war durch folgende Befunde zu belegen: 1) der IgG-Extrakt der Sera wies die gleiche inhibitorische Wirksamkeit des Hämagglutinins wie die mit RDE-behandelten Sera auf; 2) Zugabe von Protein A führte zu einer Erhöhung des HAH-Titers; 3) im Hämolysin-in-Gel-Test bildeten einige der HAH-positiven Sera Hämolyse-Ringe von gleichem Durchmesser wie ein Antiinfluenza-H1N1-Hyperimmunserum; und 4) die Sera von Hirschen und Rehen waren auch in der Inhibition der Neuraminidase (NI-Test) positiv. In einem Serum eines Hirsches wurden HI-Antikörper gegen Influenza H1N1 vor dem Auftreten dieses Virusstammes beim Menschen nachgewiesen.
Url:
DOI: 10.1007/BF01639149
Affiliations:
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Le document en format XML
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Rutter</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9B05E83ABFBEB4DA72259596BFB794DE643C0350</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1007/BF01639149</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-KJCW1J7P-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000B64</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B64</idno><idno type="wicri:Area/Istex/Curation">000B64</idno><idno type="wicri:Area/Istex/Checkpoint">001463</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001463</idno><idno type="wicri:doubleKey">0300-8126:1980:Ehrengut W:influenza:a:antibodies</idno><idno type="wicri:Area/Main/Merge">002996</idno><idno type="wicri:Area/Main/Curation">002849</idno><idno type="wicri:Area/Main/Exploration">002849</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Influenza a antibodies in cervine animals</title><author><name sortKey="Ehrengut, W" sort="Ehrengut, W" uniqKey="Ehrengut W" first="W." last="Ehrengut">W. Ehrengut</name><affiliation><wicri:noCountry code="subField">26</wicri:noCountry></affiliation></author><author><name sortKey="Sarateanu, D E" sort="Sarateanu, D E" uniqKey="Sarateanu D" first="D. E." last="Sarateanu">D. E. Sarateanu</name><affiliation><wicri:noCountry code="subField">26</wicri:noCountry></affiliation></author><author><name sortKey="Rutter, G" sort="Rutter, G" uniqKey="Rutter G" first="G." last="Rutter">G. Rutter</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Heinrich Pette Institute for Experimental Immunology and Virology, D-2000, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Infection</title><title level="j" type="sub">A Journal of INFECTIOUS Disease</title><title level="j" type="abbrev">Infection</title><idno type="ISSN">0300-8126</idno><idno type="eISSN">1439-0973</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1980-03-01">1980-03-01</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="66">66</biblScope><biblScope unit="page" to="69">69</biblScope></imprint><idno type="ISSN">0300-8126</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8126</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Animal influenza</term><term>Animal origin</term><term>Avian</term><term>Avian influenza viruses</term><term>Cervine</term><term>Cervine animals</term><term>Cervine sera</term><term>Experimental immunology</term><term>Genetic interaction</term><term>Hemagglutinin subunits</term><term>Hong kong influenza</term><term>Human sera</term><term>Human strains</term><term>Influenza</term><term>Influenza antibodies</term><term>Influenza virus</term><term>Influenza viruses</term><term>Pandemic</term><term>Pandemic influenza</term><term>Virology</term><term>Virus</term><term>Vivo production</term><term>Wide variety</term><term>Wild birds</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: In the haemagglutination inhibition (HI) test, 20 cervine sera, most of which came from Northern Germany, were treated with receptor destroying enzyme (RDE) and 11 sera were found to contain antibodies against the H1N1 (A/USSR 90/77) and H3N2 (A/Victoria 13/75, A/Texas 1/77) influenza viruses. Only two sera contained antibodies against H3N2 viruses, and seven sera were negative. Evidence of the specificity of influenza antibodies was provided by the following findings: 1) the IgG serum extracts showed the same inhibitory activity of haemagglutinin as the RDE treated sera; 2) addition of protein A led to an increase in the HI titers; 3) in the haemolysis in gel test, some of the HI positive sera formed haemolysis rings of the same diameter as hyperimmune antiinfluenza A (H1N1) serum; and 4) the cervine sera reacted positively in the neuraminidase inhibition (NI) test. It is remarkable that influenza H1N1 antibodies were found in the serum of one cervine before this virus strain appeared in humans.</div><div type="abstract" xml:lang="de">Zusammenfassung: Von 20 Sera der Spezies Cervus, meist aus Norddeutschland stammend, die mit „receptor destroying enzyme“ (RDE) behandelt worden waren, enthielten elf hämagglutinationshemmende Antikörper gegen H1N1 (A/USSR 90/77)- und H3N2 (A/Victoria 13/75, A/Texas 1/77)-Influenza-Viren. Nur zwei Sera besaßen Antikörper gegen H3N2-Viren, und sieben Sera waren sero-negativ. Die Spezifität der Antikörper war durch folgende Befunde zu belegen: 1) der IgG-Extrakt der Sera wies die gleiche inhibitorische Wirksamkeit des Hämagglutinins wie die mit RDE-behandelten Sera auf; 2) Zugabe von Protein A führte zu einer Erhöhung des HAH-Titers; 3) im Hämolysin-in-Gel-Test bildeten einige der HAH-positiven Sera Hämolyse-Ringe von gleichem Durchmesser wie ein Antiinfluenza-H1N1-Hyperimmunserum; und 4) die Sera von Hirschen und Rehen waren auch in der Inhibition der Neuraminidase (NI-Test) positiv. In einem Serum eines Hirsches wurden HI-Antikörper gegen Influenza H1N1 vor dem Auftreten dieses Virusstammes beim Menschen nachgewiesen.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><noCountry><name sortKey="Ehrengut, W" sort="Ehrengut, W" uniqKey="Ehrengut W" first="W." last="Ehrengut">W. Ehrengut</name><name sortKey="Sarateanu, D E" sort="Sarateanu, D E" uniqKey="Sarateanu D" first="D. E." last="Sarateanu">D. E. Sarateanu</name></noCountry><country name="Allemagne"><region name="Hambourg"><name sortKey="Rutter, G" sort="Rutter, G" uniqKey="Rutter G" first="G." last="Rutter">G. Rutter</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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